Fopii, photos: NBC Entertainment / Channel 4 Television

Channel 4

The show follows the lives of several employees of Sacred Heart, a teaching hospital. It features fast-paced dialogue, slapstick, and surreal vignettes presented mostly as the daydreams of the central character, Dr. John Michael "J.D." Dorian. The show's title is a play on surgical scrubs in addition to “scrubs” being slang for the new and inexperienced.

The show's narrator and main character is John "J.D." Dorian (Zach Braff), a young attending physician, who begins the series as a staff intern. He develops a close friendship with fellow intern and later private practice physician Elliot Reid (Sarah Chalke); their relationship becomes romantic on several occasions. Elliot is driven by a neurotic desire to prove her abilities to her family , her peers, and herself. J.D.'s best friend is Dr. Christopher Turk (Donald Faison), a surgical attending physician becoming the new Chief of Surgery in season eight. Turk roomed with J.D. at university at the College of William and Mary and medical school, and the two have an extremely close relationship,. During the course of the series, Turk marries Carla Espinosa (Judy Reyes), the hospital's head nurse, who acts like a mother figure to interns, often hiding their mistakes from their attending doctor.Carla is prone to overreaction and compulsively tells her friends how to go about their lives.
Two other characters play senior roles in the hospital. Dr. Percival Ulysses "Perry" Cox (John C. McGinley) was the senior attending physician at Sacred Heart and the hospital's Residency Director before becoming the new Chief of Medicine in season eight. J.D. considers Cox his mentor despite the fact that Cox routinely criticizes and belittles him. Cox frequently suggests that this harsh treatment is intended as conditioning for the rigors of hospital life. Ken Jenkins plays Dr. Bob Kelso, Sacred Heart's Chief of Medicine until the end of the seventh season when he is forced to step down from residency when the board finds out about his age, but with the help from his colleagues the decision is reversed. Having had time to think, Kelso decides to retire instead of accepting the reinstatement to Chief. Kelso is cold, heartless and cruel, driven primarily by the hospital's bottom line rather than the well-being of patients. However, it is occasionally suggested that he has a softer side, and that his cruelty is a means of coping with the years of hard decisions he has been forced to make, stating that when he became Chief of Medicine he thought he'd be "the man". Instead he very quickly realized that the harsh decisions made him unpopular, but he had to continue his "evil" facade to keep the hospital running smoothly.
The hospital custodian is known as "Janitor" played by Neil Flynn. An incident in the pilot episode establishes an adversarial relationship between him and J.D., which persists throughout the series. This tends to take the form of the Janitor pulling mean-spirited pranks on J.D.

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